Ileal sodium/bile acid cotransporter, also known as apical sodium–bile acid transporter and ileal bile acid transporter, is a bile acid:sodium symporter protein that in humans is encoded by the SLC10A2 gene. ASBT/IBAT is most highly expressed in the ileum, where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.

1994-05-01 · The Na(+)-independent transport system exhibits a substrate specificity, which is different from the specificity of Na(+)-dependent bile salt transport in mammals. Unconjugated and conjugated di- and tri-hydroxylated bile salts inhibit uptake of cholyltaurine and cholate competitively.

Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans). The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport. 23,24 There is evidence that hepatocyte entry may be a multistep process including binding to heparan sulfate proteoglycans, 25 which are found on a variety of cells, and clathrin-mediated endocytosis.

Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because the large K and Cl conductances of the sinusoidal membrane (GK and GCl, respectively) obscure any transport associated currents. 2003-07-08 Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypept …. Bile salts are the major organic solutes in It has been proposed that the hepatocellular Na (+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes. In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na (+)-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate.

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na(+)-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate. 1 ways to abbreviate Na(+)-bile Salt Co-transporter.

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2003-07-08 Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypept …. Bile salts are the major organic solutes in It has been proposed that the hepatocellular Na (+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes.

bile acid and bile salt transport Source: GO_Central "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium." Gaudet P. , Livstone M.S. , Lewis S.E. , Thomas P.D. Brief Bioinform 12:449-462(2011) [ PubMed ] [ Europe PMC ] [ Abstract ] The Na + taurocholate co-transporter (NTCP, SLC10A1) at the basolateral membrane of hepatocytes mediates bile salt (BS) uptake, whereas Na +-independent organic anion transporting polypeptides (OATPs) transport not only bile salts but also various organic anions (OA).
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How-ever, these correlations have 2017-04-20 2006-09-01 Functional Expression Cloning and Characterization of the Hepatocyte Na^+/Bile Acid Cotransport System The system operates by a sodium ion cotransport mechanism, and it functions in maintaining a normal enterohepatic circulation of bile salts. Analysis of structure-activity data allows us to depict our hypothesis for the interaction of the bile salt and Na with the membranal recognition site of this transport … 1991-12-01 2004-12-01 Figure 1.

1 ways to abbreviate Na(+)-bile Salt Co-transporter. How to abbreviate Na(+)-bile Salt Co-transporter? Get the most popular abbreviation for Na(+)-bile Salt Co-transporter updated in 2021 1992-08-01 The Na+/bile salt co-transporter of the pig ileal brush border membrane has been expressed in Xenopus laevis oocytes.
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Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans).

Kolhydrater Efter detta kan de transporteras in i cellen via Co-transport med H+.Cellens Julvi Hus i Göteborg AB. 031497575. Ingela Gathenhielms Gata 5. 421 30, VÄSTRA FRÖLUNDA. Dalkia Energy and Industrial Services AB. 0214982011.

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cells Article The Lipid Raft Component Stomatin Interacts with the Na+ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake Monique D. Appelman 1,y, Marion J.D. Robin 1,y, Esther W.M. Vogels 1, Christie Wolzak 1, Winnie G. Vos 1, Harmjan R. Vos 2, Robert M. Van Es 2, Boudewijn M.T. Burgering 2 and Stan F.J. Van de Graaf 1,3,* 1 Amsterdam UMC, University of …

The SLC10A transporter gene family consists of seven members and substrates transported by three members (SLC10A1, SLC10A2 and SLC10A6) are Na +-dependent. SLC10A1 (sodium taurocholate cotransporting polypeptide [NTCP]) and SLC10A2 (apical sodium-dependent bile salt transporter [ASBT]) transport bile salts and play an important role in maintaining enterohepatic circulation of bile salts. Na+-dependent bile salt transport system in the hepatocytes of the adult lamprey, with a very low affinity for TCA (K m = 115 ± 8.7 µM).